Figure 1. (Top) Domain structures of the REI/SH3BP5 family proteins. (Bottom) A working model of REI-1 function in C. elegans embryos. REI-1 recruits RAB-11.1 to late-Golgi by exchanging bound GDP for GTP. Activated RAB-11.1 is then distributed to the cleavage furrow via post-Golgi vesicles for proper cytokinesis.
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