4E-BP1, a multifactor regulated multifunctional protein

Figures & data

Figure 1. mTOR-independent 4E-BP1 phosphorylation is associated with colorectal cancer (CRC) resistance to mTOR kinase inhibitors (mTKIs). TIEK: TOR- independent 4E-BP1 kinase.

Table 1. Possible kinases for mTOR-independent 4E-BP1 phosphorylation.

Kinases	Condition	Phosphorylation site	References
GSK3β	N/A	Thr 37, Thr 46 (possibly Ser 65 and/or Thr 70)	^19
p38MAPK	Viral infection, TNFα/CHX-mediated apoptosis	N/A	^20,21
	UVB	Thr 36, Thr 45, Ser 64, Thr 69	^22
ERK	Ionizing radiation	Ser 65 (in vitro)	^23,24
PIM2	N/A	Ser 65	^26
ATM	Insulin treatment	Ser 112	^29
CDC2/CDK1	Paclitaxel (PTX) treatment	Thr 70	^30,31
LRRK2	Physiological condition	Thr 37, Thr 46	^32

Possible mTOR-independent 4E-BP1 kinases and corresponding phosphorylation condition and site were listed. For a review see refs. 19–32.

Figure 2. Overexpression of 4E-BP1 has been found in various carcinomas. Original data from https://www.oncomine.com was analyzed and plotted into a bar graph. Studies that showed higher 4E-BP1 level in cancer tissue vs. normal tissue are depicted in red and others in blue.

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