Figures & data
Figure 1. The Role of DNA Double Strand Break and the NHEJ Signaling Pathway in Transcription of Inducible Genes. We depict recruitment to gene promoters, by a transcription factor dimer, of a complex containing NHEJ proteins including DNA-PK, as well as Topoisomerase IIβ and PARP1. Following generation of a DSB in the promoter by Topoisomerase IIβ, DNA repair pathways are triggered, resulting in the activation of DNA-PK that phosphorylates substrates such as H2AX and Kap1/TRIM28 throughout the transcribing gene, permitting RNA elongation by Pol II.
![Figure 1. The Role of DNA Double Strand Break and the NHEJ Signaling Pathway in Transcription of Inducible Genes. We depict recruitment to gene promoters, by a transcription factor dimer, of a complex containing NHEJ proteins including DNA-PK, as well as Topoisomerase IIβ and PARP1. Following generation of a DSB in the promoter by Topoisomerase IIβ, DNA repair pathways are triggered, resulting in the activation of DNA-PK that phosphorylates substrates such as H2AX and Kap1/TRIM28 throughout the transcribing gene, permitting RNA elongation by Pol II.](/cms/asset/ea9b5699-4098-4719-bfa0-37299b2f53a4/kccy_a_1154370_f0001_oc.gif)