Figures & data
Figure 1. CD82(KAI1) on LT-HSCs interacts with its binding partner DARC expressed on macrophages, to maintain LT-HSC quiescence. This is a metaphorical image depicting the relationship of DARC+ macrophages (black-furred mother cat), CD82+ LT-HSCs (white-furred kittens) and other haematopoietic stem-progenitors (gray-furred kittens). When the mother holds the kittens in her forelegs in the dark (DARC), they fall asleep. During the day (the absence of macrophagic DARC), the mother lets her kittens out; they then wake up and undergo proliferation and differentiation.
