Figures & data
Figure 1. Positive feedback loops underlying regulation of the CPC. Proper centromeric localization and function of the CPC is regulated by multiple positive feedback loops based on Aurora B activity. HP1-assisted Aurora B full activity in non-transformed cells forms more robust feedback loops than that in cancer cells. Cancer cells have system-level deficiencies in Aurora B control by incomplete HP1 binding.
![Figure 1. Positive feedback loops underlying regulation of the CPC. Proper centromeric localization and function of the CPC is regulated by multiple positive feedback loops based on Aurora B activity. HP1-assisted Aurora B full activity in non-transformed cells forms more robust feedback loops than that in cancer cells. Cancer cells have system-level deficiencies in Aurora B control by incomplete HP1 binding.](/cms/asset/4a7d8d1d-df2f-4aeb-a4b4-758a051320d0/kccy_a_1185850_f0001_oc.gif)