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Editorials: Cell Cycle Features

New insights into Cdk2 regulation during meiosis

, &
Pages 2681-2682 | Received 07 Jun 2016, Accepted 11 Jun 2016, Published online: 29 Jul 2016

Figures & data

Figure 1. The Cdk2 activator RingoA is essential for the progression of germ cells through meiotic prophase I. Loss of RingoA arrests mouse germ cells in a pachytene-like stage with defective telomere tethering to the inner nuclear membrane (INM), non-homologous chromosome synapsis and telomere fusion, eventually leading to apoptosis.

Figure 1. The Cdk2 activator RingoA is essential for the progression of germ cells through meiotic prophase I. Loss of RingoA arrests mouse germ cells in a pachytene-like stage with defective telomere tethering to the inner nuclear membrane (INM), non-homologous chromosome synapsis and telomere fusion, eventually leading to apoptosis.

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