Figure 1. The life cycle of blebs is governed by 2 small GTPases. Rnd3 is preferentially recruited to the actin cortex-free membrane protrusion. During expansion phase, reassembly of actin cortex was actively suppressed by Rnd3-p190BRhoGAP complex and bleb continues to expand passively by the intracellular pressure. Sporadic activation of RhoA is stabilized locally by the phosphorylation of Rnd3 by RhoA-ROCK pathway because phosphorylated Rnd3 is removed from the plasma membrane.
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