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Cell Cycle Volume 15, 2016 - Issue 22
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Editorials: Cell Cycle Features

How membrane asymmetry regulates ADAM17 sheddase function

Anselm SommerDepartment of Dermatology, University of Kiel, Kiel, Germany
,
Sucharit BhakdiDepartment of Dermatology, University of Kiel, Kiel, Germany
&
Karina ReissDepartment of Dermatology, University of Kiel, Kiel, GermanyCorrespondence[email protected]
Pages 2995-2996 | Received 15 Jun 2016, Accepted 23 Jun 2016, Published online: 19 Aug 2016

Figures & data

Figure 1. Role of PS-exposure for ADAM17 function. Many cellular stimuli provoke transient translocation of PS. Electrostatic interaction with the membrane proximal domain (MPD) of ADAM17 together with membrane association of the neighboring CANDIS-helix then enable substrate processing to take place.

Figure 1. Role of PS-exposure for ADAM17 function. Many cellular stimuli provoke transient translocation of PS. Electrostatic interaction with the membrane proximal domain (MPD) of ADAM17 together with membrane association of the neighboring CANDIS-helix then enable substrate processing to take place.

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