Figure 1. (Left) localization of Venus-PRICKLE1 at the leading edge of a migratory MDA-MB231 breast cancer cell. (Right) schematic of PRICKLE1 recruitment at the plasma membrane. Phosphorylation of PRICKLE1 by MINK1 leads to the localization of the PRICKLE1-mTORC2 protein complex and to AKT phosphorylation. The four main questions to answer (see text) are numbered in red.
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