Figures & data
Figure 1. Schematic diagram of RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs. Activation of TNF receptors 1/2 activates RIPK1/RIPK3, together with loss of cIAPs resulting in the induction of regulated necrosis and inflammasome formation, propagating proinflammatory signaling and substantial cytokine secretion. Several AML subtypes including FLT3-ITD show reduced expression of RIPK3 and MLKL, preventing LIC cell death and IL-1β production.
![Figure 1. Schematic diagram of RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs. Activation of TNF receptors 1/2 activates RIPK1/RIPK3, together with loss of cIAPs resulting in the induction of regulated necrosis and inflammasome formation, propagating proinflammatory signaling and substantial cytokine secretion. Several AML subtypes including FLT3-ITD show reduced expression of RIPK3 and MLKL, preventing LIC cell death and IL-1β production.](/cms/asset/0a4ca36c-9eda-4ce0-98ec-b6df4c325ae5/kccy_a_1232069_f0001_oc.gif)