Figure 1. Sustained mTORC1 activity in the absence of PI3K/AKT signaling by SGK kinases. SGK1/3 are transcriptionally regulated and activated by mTORC2 and PDK1 phosphorylation. SGK3 is recruited at the endosomal membrane interacting with PI(3)P, which results from VPS34 enzymatic activity. SGK kinases have the ability to phosphorylate TSC2, the GTPase Activating Protein for RHEB, the upstream activator of mTORC1.
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