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Editorials: Cell Cycle Features

Dynein: Let’s not get stuck!

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Pages 7-8 | Received 24 Aug 2016, Accepted 27 Aug 2016, Published online: 01 Nov 2016

Figures & data

Figure 1. Cartoon of a lipid droplet in the optical trap. Lower: dark circle: lipid droplet; red parabolic lines: optical trap, exerting a centripetal force (red arrow) on the droplet when displaced from trap center. Horizontal black lines: dynein motors, attached to microtubule (blue). Upper: enlargement of the lower portion of the lipid droplet, showing attached dynein motors in black, with NudE (red) and Lis1 (green) cofactors. Two dyneins on left: pre-adaptation stage, with un-extended NudE (red, short) and Lis1 (green) that is not interacting with the dynein motor domains (ovals). Five dyneins on right: adapted dynein; NudE extended, Lis1 interacting with the dynein motor domains.

Figure 1. Cartoon of a lipid droplet in the optical trap. Lower: dark circle: lipid droplet; red parabolic lines: optical trap, exerting a centripetal force (red arrow) on the droplet when displaced from trap center. Horizontal black lines: dynein motors, attached to microtubule (blue). Upper: enlargement of the lower portion of the lipid droplet, showing attached dynein motors in black, with NudE (red) and Lis1 (green) cofactors. Two dyneins on left: pre-adaptation stage, with un-extended NudE (red, short) and Lis1 (green) that is not interacting with the dynein motor domains (ovals). Five dyneins on right: adapted dynein; NudE extended, Lis1 interacting with the dynein motor domains.

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