Figures & data
Figure 1. ROS in translation—The battle between oxidants and antioxidants. Protein synthesis is a key physiological task of cancer cells and plays an essential role in oncogenic transformation. Through activation of NRF2, intracellular antioxidants play a critical role in protecting the integrity of the cancer cell translation machinery. As a therapeutic strategy, oxidants can be used to breach the antioxidant protective barrier to hamper protein synthesis and thus pancreatic cancer cell survival.
