Figure 1. Model for the role(s) of centromeric transcription in kinetochore assembly. Nascent RNA Polymerase II (Pol II) transcripts stabilize CENP-C at the centromere, which promotes kinetochore assembly leading to spindle microtubule attachment. Active Pol II also recruits splicing factors that process nascent centromeric RNAs and could catalyze functionally important post-translational modifications (PTM) of kinetochore proteins.
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