Figure 1. Translational control by Nelfinavir. Nelfinavir inhibits translation initiation by triggering the phosphorylation of eIF2α. Moreover, Nelfinavir promotes the activation of the kinase eEF2K leading to the phosphorylation of the elongation factor eEF2, thereby blocking its ability to promote translation elongation. In addition eEF2K activation may affect a yet to be defined step in the initiation process. EEF2K activation by Nelfinavir dampens tumor growth.
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