Adaptive aneuploidy counters a dysregulated SUMO system

Figures & data

Figure 1. Overproduced Ccr4 or Cln3 suppresses aneuploidy triggered by loss of Ulp2. Loss of Ulp2 (top right) leads to accumulation of polySUMO-conjugated substrates, duplication of Chromosome I (ChrI) and XII, and reduced cell fitness (irregular cell outline). Increased dosage of CCR4 (bottom left) suppresses the aneuploidy and growth defects and partially reduces the aberrantly high SUMO-conjugate levels of ulp2Δ cells (Ref.⁴ and unpublished data). Overexpressing CLN3 (bottom right) suppresses the ChrI, but not ChrXII, disomy, likely through (partial) normalization of cell-cycle progression.

Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes Dev 2016; 30:1881-1894; PMID:27585592; https://dx.doi.org/10.1101/gad.282194.116

 Google Scholar