Figures & data
Figure 1. Cytosolic and mitochondrial tetrahydrofolate (THF) metabolism. The numbers in the figure correspond to the following enzymes: 1) SHMT2, serine hydroxymethyltransferase 2; 2) GLDC, Glycine dehydrogenase (decarboxylating), mitochondrial; 3) MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (expressed in normal cells and employing both NAD+ and NADP+); 4) MTHFD2L, MTHFD2-like (employing mostly NAD+) and expressed predominantly in cancer cells; 5) MTHFD1L, formyltetrahydrofolate synthetase; 6) ALDH1L2, Aldehyde Dehydrogenase 1 Family Member L2; 7) SHMT1 serine hydroxymethyltransferase 1; 8) MTHD1, trifunctional enzyme with the following activityies methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase and formate–tetrahydrofolate ligase; 9) MTHFR, Methylene tetrahydrofolate reductase; 10) TYMS, thymidylate synthase; 11) ALDH1L1, Aldehyde Dehydrogenase 1 Family Member L1; 12) PDC, Pyruvate dehydrogenase complex; 13) IDH3, Isocytric dehydrogenase 3; 14) KGDHC, α-ketoglutarate dehydrogenase complex; 15) MDH, Malate dehydrogenase; 16) NNT, Nicotinamide Nucleotide Transhydrogenase.
