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Cell Cycle Volume 16, 2017 - Issue 13
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Salmonella typhimurium A1-R targeting of a chemotherapy-resistant BRAF-V600E melanoma in a patient-derived orthotopic xenograft (PDOX) model is enhanced in combination with either vemurafenib or temozolomide

Kei KawaguchiAntiCancer, Inc., San Diego, CA, USA;Department of Surgery, University of California, San Diego, CA, USA;Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan
,
Kentaro IgarashiAntiCancer, Inc., San Diego, CA, USA;Department of Surgery, University of California, San Diego, CA, USA
,
Takashi MurakamiAntiCancer, Inc., San Diego, CA, USA;Department of Surgery, University of California, San Diego, CA, USA
,
Tasuku KiyunaAntiCancer, Inc., San Diego, CA, USA;Department of Surgery, University of California, San Diego, CA, USA
,
Ming ZhaoAntiCancer, Inc., San Diego, CA, USA
,
Yong ZhangAntiCancer, Inc., San Diego, CA, USA
,
Scott D. NelsonDepartment of Pathology, University of California, Los Angeles, CA, USA
,
Tara A. RussellDivision of Surgical Oncology, University of California, Los Angeles, CA, USAORCID Iconhttp://orcid.org/0000-0002-3912-3601
ORCID Icon,
Sarah M. DryDepartment of Pathology, University of California, Los Angeles, CA, USA
,
Arun S. SinghDivision of Hematology-Oncology, University of California, Los Angeles, CA, USA
,
Bartosz ChmielowskiDivision of Hematology-Oncology, University of California, Los Angeles, CA, USAORCID Iconhttp://orcid.org/0000-0002-2374-3320
ORCID Icon,
Yunfeng LiDepartment of Pathology, University of California, Los Angeles, CA, USA
,
Michiaki UnnoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan
,
Fritz C. EilberDivision of Surgical Oncology, University of California, Los Angeles, CA, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3336-9333
ORCID Icon &
Robert M. HoffmanAntiCancer, Inc., San Diego, CA, USA;Department of Surgery, University of California, San Diego, CA, USACorrespondence[email protected]
 show all
Pages 1288-1294 | Received 15 Feb 2017, Accepted 27 Mar 2017, Published online: 26 Jun 2017

Figures & data

Figure 1. Representative photographs of mice from each treatment group. A. Untreated control. B. Treated with S. typhimurium A1-R. C. Treated with TEM and S. typhimurium A1-R. D. Treated with VEM and S. typhimurium A1-R. Scale bar: 5 mm.

Figure 1. Representative photographs of mice from each treatment group. A. Untreated control. B. Treated with S. typhimurium A1-R. C. Treated with TEM and S. typhimurium A1-R. D. Treated with VEM and S. typhimurium A1-R. Scale bar: 5 mm.

Figure 2. Relative tumor volume in the various treatment groups. Bar graph shows relative tumor volume at post-treatment point relative to the initial pre-treatment tumor volume. Error bars: ± SD.

Figure 2. Relative tumor volume in the various treatment groups. Bar graph shows relative tumor volume at post-treatment point relative to the initial pre-treatment tumor volume. Error bars: ± SD.

Figure 3. Fluorescence imaging of S. typhimurium A1-R-GFP targeting alone and in combination with chemotherapy in the melanoma PDOX. Confocal imaging with the FV1000. Scale bars: 12.5 μm.

Figure 3. Fluorescence imaging of S. typhimurium A1-R-GFP targeting alone and in combination with chemotherapy in the melanoma PDOX. Confocal imaging with the FV1000. Scale bars: 12.5 μm.

Figure 4. Quantitative tumor targeting by S. typhimurium A1-R-GFP alone and in combination with chemotherapy on the melanoma PDOX model. Bar graphs show S. typhimurium A1-R-GFP fluorescent area (μmCitation2) for each treatment group. Error bars: ± SD.

Figure 4. Quantitative tumor targeting by S. typhimurium A1-R-GFP alone and in combination with chemotherapy on the melanoma PDOX model. Bar graphs show S. typhimurium A1-R-GFP fluorescent area (μmCitation2) for each treatment group. Error bars: ± SD.

Figure 5. Histological analysis. Hematoxylin and eosin (H&E) stained slides from tumor tissue of each treatment group. A. Untreated control. B. S. typhimurium A1-R alone. C. S. typhimurium A1-R and TEM. D. S. typhimurium A1-R and VEM. Scale bars: 100 μm.

Figure 5. Histological analysis. Hematoxylin and eosin (H&E) stained slides from tumor tissue of each treatment group. A. Untreated control. B. S. typhimurium A1-R alone. C. S. typhimurium A1-R and TEM. D. S. typhimurium A1-R and VEM. Scale bars: 100 μm.

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