Figures & data
Figure 1. Integrin β3 (αvβ3) regulates senescence and is highly expressed during aging. The levels of αvβ3 (dark/light green hooks) increase progressively upon the induction of cellular senescence and aging. In fact, there are very low levels of expression of αvβ3 in proliferating cells (left panel). However, once senescence is established, αvβ3 expression increases inducing the release of TGFβ (middle panel), which is capable of activating senescence in an autocrine (middle panel) and paracrine fashion (right panel).
