Figures & data
Figure 1. Cytidine deaminase deficiency leads to dCTP intracellular accumulation reducing basal PARP-1 activity. In consequence, Chk1 activation and the subsequent S and G2/M checkpoint efficiencies are reduced allowing the premature entry of cells into mitosis before complete DNA replication. During mitosis, the accumulation of unreplicated DNA sequences, in particular at difficult-to-replicate sites such as centromeres and common fragile sites, leads to mitotic DNA synthesis, ultrafine anaphase bridge (UFB) formation and incomplete sister chromatid disjunction in cohesin-depleted cells.
