Arpp19 in prophase I resumption

Figures & data

Figure 1. How phosphorylation controls Arpp19 functions? PKA phosphorylates S109 of Arpp19 at prophase I of meiosis. Hormonal stimulation promotes S109 dephosphorylation. The phosphatase responsible of this dephosphorylation remains to be characterized. Next, Gwl phosphorylates S67 of Arpp19 and an unknown kinase phosphorylates S109 of Arpp19 protein.⁵

Dupré A, Daldello EM, Nairn AC, Jessus C, Haccard O. Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes. Nat Commun 2014; 5:3318; PMID:24525567; https://doi.org/10.1038/ncomms4318

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