Figures & data
Figure 1. Context-dependent functions of mTORC1 signaling in Schwann cells (SCs). Schematic graph showing developmental downregulation of SC mTORC1 activity to basal levels in adulthood. The mTORC1 decline is necessary for the differentiation of SC precursors to mature SCs that myelinate axons. While mTORC1 activity promotes proliferation of SC precursors during development, it stimulates myelin growth in adulthood. mTORC1 activity in SCs is adjusted by the TSC complex, which is negatively regulated by various upstream pathways.
