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New roles for Dicer in the nucleolus and its relevance to cancer

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Pages 1643-1653 | Received 18 Jul 2017, Accepted 25 Jul 2017, Published online: 30 Aug 2017

Figures & data

Figure 1. Overview of nucleolar structure and function. RNA polymerase I transcribes the rDNA repeats at the interface between the fibrillar center (FC) and the dense fibrillar component (DFC). rRNA molecules and ribosomal proteins associate in complexes in the granular component (GC), and are exported outside of the nucleolus as immature ribosomal particles, which are then assembled into ribosomes.

Figure 1. Overview of nucleolar structure and function. RNA polymerase I transcribes the rDNA repeats at the interface between the fibrillar center (FC) and the dense fibrillar component (DFC). rRNA molecules and ribosomal proteins associate in complexes in the granular component (GC), and are exported outside of the nucleolus as immature ribosomal particles, which are then assembled into ribosomes.

Figure 2. DICER1 is frequently mutated in cancer. Overview of DICER1 mutations found in several cancer types, as described inCitation108-130 and in NCBI ClinVar. The majority of mutations are predicted to be heterozygous germline loss-of-function alleles, while the hotspot for somatic mutations is located at the RNase IIIb domain catalytic residues.

Figure 2. DICER1 is frequently mutated in cancer. Overview of DICER1 mutations found in several cancer types, as described inCitation108-130 and in NCBI ClinVar. The majority of mutations are predicted to be heterozygous germline loss-of-function alleles, while the hotspot for somatic mutations is located at the RNase IIIb domain catalytic residues.