Figures & data
Figure 1. Working model for CLIC3-TGM2. In the reducing intracellular environment CLIC3 is reduced in a GSH-dependent manner and secreted in the oxidative extracellular environment. Extracellularly, CLIC3 reduces (activates) TGM2, which, in turn, stiffens the extracellular matrix (ECM) and activate α5β1 integrin signalling in cancer and endothelial cells, thus inducing tumour invasion and blood vessel growth.
