http://orcid.org/0000-0002-1073-7917, & Figure 1. A schematic model illustrating how SPOP governs the BET protein stability and controls resistance to BET inhibitors. Prostate cancer cells with SPOP mutation exhibited increased resistance to BET inhibitor, where endometrial cancer-associated SPOP mutants lead to sensitization to BET inhibitors in endometrial cancer.
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