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Cell Cycle News & Views

Better together: Unifying discordant cell-cycle oscillator models

Pages 9-10 | Received 27 Sep 2017, Accepted 03 Oct 2017, Published online: 02 Jan 2018

Figures & data

Figure 1. Models past and present of the drivers of global transcriptional oscillations during the eukaryotic cell cycle in yeast. The CDK-APC oscillator controls a global transcriptional oscillator (top); a global transcriptional oscillator directly regulates oscillations in global transcription and CDK1-cyclin B activity, while CDK1-APC oscillations also impact global transcriptional oscillations (center); or, a global transcriptional oscillator drives periodic transcription and is influenced by signal amplification through CDK activity, and vice versa (bottom). All enclosed components indicated are control elements; components indicated by arrowheads are outputs.

Figure 1. Models past and present of the drivers of global transcriptional oscillations during the eukaryotic cell cycle in yeast. The CDK-APC oscillator controls a global transcriptional oscillator (top); a global transcriptional oscillator directly regulates oscillations in global transcription and CDK1-cyclin B activity, while CDK1-APC oscillations also impact global transcriptional oscillations (center); or, a global transcriptional oscillator drives periodic transcription and is influenced by signal amplification through CDK activity, and vice versa (bottom). All enclosed components indicated are control elements; components indicated by arrowheads are outputs.

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