Selective autophagy restricts IL-9 secretion from T_H9 cells: relevance in cancer growth

Figures & data

Figure 1. Selective autophagy prevents T_H9 cell differentiation. During T_H9 cell differentiation ubiquitinated (Ub) PU.1 is recruited by p62, which recognizes K63 ubiquitination through its UBA domain. PU.1 is then degraded by selective autophagy, which leads to reduced IL-9 expression and anticancer immune responses in the tumor microenvironment. Chloroquine treatment, which inhibits lysosomal functions, prevents PU.1 degradation and drives enhanced T_H9 cell-derived IL-9 secretion and anticancer effects.