http://orcid.org/0000-0002-4629-496XView further author informationFigure 1. BLM promotes (a) initial ‘resection’ of DNA double-strand breaks during homologous recombination (HR), but, (b) as reinforced by recent data, also destabilizes RAD51 at resected DNA breaks. This inhibitory effect of BLM may help ensure recombination only takes place between highly-homologous sequences. BLM also acts to (c) disassemble ‘D-loops’ formed after pairing of homologous sequences, and (d) in ‘dissolution’ of HR intermediates.
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