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Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients

Kei KawaguchiAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, JapanView further author information

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Kentaro IgarashiAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USAView further author information

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Tasuku KiyunaAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USAView further author information

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Kentaro MiyakeAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USAView further author information

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Masuyo MiyakeAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USAView further author information

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Takashi MurakamiAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USAView further author information

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Bartosz ChmielowskiDivision of Hematology-Oncology, University of California, Los Angeles, CA, USA

http://orcid.org/0000-0002-2374-3320 View further author information

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Scott D. NelsonDepartment of Pathology, University of California, Los Angeles, CA, USAView further author information

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Tara A. RussellDivision of Surgical Oncology, University of California, Los Angeles, CA, USA

http://orcid.org/0000-0002-3912-3601 View further author information

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Sarah M. DryDepartment of Pathology, University of California, Los Angeles, CA, USAView further author information

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Yunfeng LiDepartment of Pathology, University of California, Los Angeles, CA, USAView further author information

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Arun S. SinghDivision of Hematology-Oncology, University of California, Los Angeles, CA, USAView further author information

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Michiaki Unno Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, JapanView further author information

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Fritz C. EilberDivision of Surgical Oncology, University of California, Los Angeles, CA, USACorrespondence[email protected]

http://orcid.org/0000-0003-3336-9333 View further author information

&

Robert M. HoffmanAntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USACorrespondence[email protected]
View further author information

Figures & data

Table 1. Patients characteristics.

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Figure 1. DOX sensitivity of 5 different USTS PDOX models. Bar graphs show relative tumor volume at post-treatment relative to pre-treatment tumor volume. Error bars: ± SD.

Figure 1. DOX sensitivity of 5 different USTS PDOX models. Bar graphs show relative tumor volume at post-treatment relative to pre-treatment tumor volume. Error bars: ± SD.

Figure 2. Treated and untreated PDOX tumors. Tumors from USTS PDOX models of patients 1 and 4 are shown before and after treatment with DOX. Scale bar: 5 mm.

Figure 2. Treated and untreated PDOX tumors. Tumors from USTS PDOX models of patients 1 and 4 are shown before and after treatment with DOX. Scale bar: 5 mm.

Figure 3. Effect of each treatment on mouse body weight. Bar graphs shows mouse body weight in each mouse at pre- and post-treatment.

Figure 3. Effect of each treatment on mouse body weight. Bar graphs shows mouse body weight in each mouse at pre- and post-treatment.

Figure 4. Tumor histology. Tumors from PDOX models 1 and 4 are shown both untreated and after treatment. Scale bars: 50 μm.

Figure 4. Tumor histology. Tumors from PDOX models 1 and 4 are shown both untreated and after treatment. Scale bars: 50 μm.

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