https://orcid.org/0000-0001-6758-9276
Figures & data
Figure 1. The CRL1 and CRL3 complex. The CRLs are multi-subunit E3s complexes, which assemble using one of the five CULLIN proteins as a core scaffold. (a) The CULLINS recruit a small RING protein (Rbx1) and an E2 enzyme via the C-terminus. The N-terminus binds the bridging factors, which determine substrate specificity. (b) The CRL1 complex featuring the Skp1-F-box as the substrate adapter unit. (c) The CRL3 complex featuring the BTB-protein as the substrate adaptor unit.
Figure 2. Model of KLHL6-Roquin2 axis in ABC-DLBCL. In physiologic B-cell receptor signaling (upper panel), KLHL6 is up-regulated upon antigen-induced BCR/NF-κB activation. High levels of KLHL6 induce proteasomal degradation of Roquin2, resulting in A20 accumulation due to low mRNA decay. A20 negatively regulates BCR signaling by inhibiting the IKK complex. In DLBCLs harboring KLHL6 mutations (lower panel), Roquin2 degradation is impaired, resulting in higher A20 mRNA decay and constitutive activation of IKK.
