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Cell Cycle Volume 18, 2019 - Issue 11
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Letter to the Editor

Loss of β-arrestin-2 gene and possible functional consequences on Sezary Syndrome

Cristina CristofolettiLaboratory of Molecular Oncology, IDI-IRCCS, Rome, ItalyView further author information
,
Antonella BresinLaboratory of Molecular Oncology, IDI-IRCCS, Rome, ItalyView further author information
,
Elisabetta CapriniLaboratory of Molecular Oncology, IDI-IRCCS, Rome, ItalyView further author information
,
Giandomenico RussoLaboratory of Molecular Oncology, IDI-IRCCS, Rome, ItalyView further author information
&
Maria Grazia NarducciLaboratory of Molecular Oncology, IDI-IRCCS, Rome, ItalyCorrespondence[email protected]
View further author information
Pages 1292-1294 | Received 08 Feb 2019, Accepted 18 Apr 2019, Published online: 20 May 2019

Figures & data

Figure 1. ARRB2 Depletion decreases CXCR4 internalization and migration index upon SDF-1 treatment.

(A) H9 cells depleted ofARRB2 by siRNA transfection (lower panel) show an increased number of CXCR4+cells upon SDF-1 treatment, when compared to scrambled control (upper panel). One representative experiment is shown in figure (n = 4, 66 ± 8,57 vs 54,93 ± 6,05; P = 0.039). (B) Western blot analysis confirms a reduction of ARRB2 protein in siRNA-transfected H9 cells respect to control (scr-siRNA) after 48 and 72 hours. (C) H9 cells (ARRB2 CN gain) show a higher migration response to SDF-1 than Hut78 cells (ARRB2W1) (n.4, FC = 3,85, P < 0.001).

Figure 1. ARRB2 Depletion decreases CXCR4 internalization and migration index upon SDF-1 treatment.(A) H9 cells depleted ofARRB2 by siRNA transfection (lower panel) show an increased number of CXCR4+cells upon SDF-1 treatment, when compared to scrambled control (upper panel). One representative experiment is shown in figure (n = 4, 66 ± 8,57 vs 54,93 ± 6,05; P = 0.039). (B) Western blot analysis confirms a reduction of ARRB2 protein in siRNA-transfected H9 cells respect to control (scr-siRNA) after 48 and 72 hours. (C) H9 cells (ARRB2 CN gain) show a higher migration response to SDF-1 than Hut78 cells (ARRB2W1) (n.4, FC = 3,85, P < 0.001).

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