Abnormally high expression of HOXA2 as an independent factor for poor prognosis in glioma patients

Figures & data

Figure 1. HOXA2 expression in glioma. Association with expression and clinicopathologic characteristics, including a: Age, b: Grade, c: PRS_type, d: 1p19q_codeletion status, e: IDH mutation status f: Histology.

Figure 2. The Kaplan-Meier survival curve and The ROC curve. a: High expression of HOXA2 leads to poor overall survival in glioma patients. b: The ROC curve show good diagnosis value of HOXA2 expression in glioma.

Figure 3. Univariate regression of prognostic in patients with glioma.

Figure 4. Multivariate survival model of prognostic in patients with glioma.

Table 1. The gene set enriches the high HOXA2 expression phenotype.

Gene set name	NES	NOM p-val	FDR q-val
KEGG_JAK_STAT_SIGNALING_PATHWAY	1.7091726	0.0256	0.1622
KEGG_FOCAL_ADHESION	1.6964064	0.0291	0.1679
KEGG_CELL_ADHESION_MOLECULES_CAMS	1.6573308	0.0449	0.1865
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY	1.6244318	0.0299	0.1804
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	1.7263384	0.0282	0.1926

NES: normalized enrichment score; NOM: nominal; FDR: false discovery rate. Gene sets with NOM P-value <0.05 and FDR q-value <0.25 were considered as significantly enriched.

Figure 5. Enrichment plots from GSEA. a:JAK-STAT-signaling pathway; b:focal adhesion; c:cell-adhesion-molecules-CAMS pathway; d:cytosolic DNA sensing pathway; e:natural killer cell-mediated cytotoxicity.

Figure 6. TGCA database verification survival analysis and RT-qPCR verification results.a: The diff figure showed that the HOXA2 expression increased significantly in glioma; b: The Kaplan-Meier curve based on TCGA database show that high expression of HOXA2 can lead to poor prognosis in patients with glioma. c: The results of PCR verification showed that HOXA2 was highly expressed in glioma patients.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article.