Regulation of DNA duplication by the mTOR signaling pathway

Figures & data

Figure 1. The identified protein complexes that are formed by mTOR kinase, and their proved or potential (labeled with “?” mark) roles and mechanisms in the regulation of physiology of normal cells or cancer cells. DDR, DNA damage response; CSC, cancer stem cell. “?” denotes an unidentified mechanism

Figure 2. mTOR promotes cycle progression through multiple mechanisms. mTOR promotes replication licensing by enhancing MCM2–7 loading via regulating CDC6; mTOR accelerates DNA replication progression through upregulating RNR to provide dNTPs and increasing CDC6; mTOR maintains replication fork stability via sustaining CHK1 and FANCD2