https://orcid.org/0000-0002-9063-6840
Figures & data
Figure 1. Timeline of Active RB expression and Dispersion. The illustration shows the major changes observed progressively 0, 24, 48, and 72 h after the DOX-induced replacement of the endogenous RB by exogenous active forms of RB. The active RB-mediated chromatin dispersion and induction of autophagy program occurs much later than active RB-induced G1 arrest and repression of E2F targets. Dispersion measures and autophagy response increase between 48 and 72 h.
Figure 2. Possible chronology of events after the expression of constitutively active ∆CDK RB. The first two scenarios explore the relationship between dispersion and autophagy and its contribution to senescence/presenescence. The third scenario speculates that both dispersion and autophagy response occur as a consequence of presenescence/senescence onset. The solid black arrow represents the DOX-induced expression of active RB. The red arrow shows onset of cell cycle arrest and the prolonging of the arrest. Dashed arrows indicate the progress of time with respect to the major events shown.
