COPD: Magnesium in the Plasma and Polymorphonuclear Cells of Patients During a Stable Phase

Figures & data

Table 1 Pulmonary function test for patients with COPD, healthy control non-smokers and smokers

	COPD X	Healthy non-	Healthy smokers
	(±SD)	smokers X (± SD)	X (± SD)
FEV1 %	49.26 (14.58)	103.19 (18.41)	102.12 (19.54)
FEV1/FVC × 100	51.29 (9.75)	80.83 (5.45)	81.53 (6.57)

FEV₁%—forced expiratory volume in 1 sec.

FEV₁/FCV—ratio of forced expiratory volume in 1 sec. and forced volume capacity.

Table 2 Median, mean, and ranges for concentration of total and ionized magnesium (tMg and iMg) and total and ionized calcium (tCa and iCa) and their ratios in COPD patients and control subjects of healthy non-smokers and healthy smokers

	COPD (n = 46)		Healthy non-smokers (n = 37)		Healthy smokers (n = 24)
	plasma (mmol/L)	PMN (μ mol/10^9 cells)	plasma (mmol/L)	PMN (μ mol/10^9 cells)	plasma (mmol/L)	PMN (μ mol/10^9 cells)
analyts	median (mean) (range)	median (mean) (range)	median (mean)(range)	median (mean) (range)	median (mean) (range)	median (mean) (range)
iMg	0.55 (0.54)	5.42 (6.65)	0.56 (0.56)	7.50 (7.86)	0.51 (0.53)	5.59 (6.68)
	(0.39–0.72)	(1.98–17.31)	(0.44–0.71)	(3.27–15.15)	(0.43–0.70)	(2.30–13.79)
tMg	0.85 (0.83)	3.96 (4.50)	0.85 (0.86)	4.11 (4.66)	0.85 (0.87)	3.89 (4.23)
	(0.57–1.03)	(1.61–11.32)	(0.64–1.03)	(1.50–11.59)	(0.75–1.07)	(2.08–8.04)
iCa	1.25 (1.25)	8.06 (9.45)	1.27 (1.28)	10.00 (10.52)	1.27 (1.27)	6.92 (8.73)
	(1.00–1.43)	(2.73–28.84)	(1.01–1.55)	(3.74–26.39)	(1.10–1.40)	(2.30–22.95)
tCa	2.42 (2.42)	5.26 (10.34)	2.31 (2.36)	3.03 (3.51)	2.28 (2.31)	2.72 (3.59)
	(2.20–2.64)	(0.24–50.94)	(2.15–3.32)	(0.47–16.67)	(2.10–2.50)	(0.62–16.39)
iCa/iMg	2.32 (2.31)	1.42 (1.41)	2.28 (2.29)	1.28 (1.31)	2.45 (2.44)	1.22 (1.26)
	(1.72–3.28)	(0.75–2.83)	(1.77–2.90)	(0.87–1.90)	(1.82–3.00)	(0.90–2.00)
tCa/tMg	2.89 (2.91)	1.19 (1.95)	2.65 (2.70)	0.67 (0.77)	2.58 (2.67)	0.66 (0.78)
	(2.15–3.86)	(0.07–9.87)	(2.19–3.44)	(0.14–2.40)	(2.26–3.24)	(0.14–2.85)

*Statistically significant differences compared to the control group of healthy non-smokers; Mann–Whitney U-test < 0.05.

•Statistically significant differences compared to the control group of healthy smokers; Mann–Whitney U-test < 0.05.

Table 3 The results of univariant logistic regression analysis for smoking, concentration of tCa and ratio of tCa/tMg in PMN as independent variable and for COPD status as dependent variable

Variable N = 103	Odds ratio	95% CI	p
Smoking	4.765	2.012–11.285	0.00005
ln tCa in PMN	1.757	1.092–2.829	0.02
ln tCa/tMg in PMN	2.184	1.215–3.926	0.009

ln tCa logarithm for concentration of total calcium;

ln tCa/tMg logarithm for ratio of total calcium/total magnesium.