The Relationship Between Exercise Tolerance and Other Outcomes in COPD

Figures & data

Table 1 Correlations between activities of daily living assessed from generic Health-related Quality of Life instruments and measures of exercise tolerance

Activities of daily living	Exercise tolerance	Correlation
SF-36 Physical Component ([56])	6 MW distance	0.19
	Wmax	0.18
SF-36 Physical Component ([57])	6 MW distance	0.41
SF-36 Physical Component ([45])	6 MW distance	0.67
SF-36 Physical Component ([58])	6 MW distance	0.38
Sickness Impact Profile Physical Component ([59])	6 MW distance	−0.72
Sickness Impact Profile Physical Component ([60])	6 MW distance	−0.38

6 MW = 6-minute walk, Wmax = maximal work rate performed on a cycle ergometer.

Table 2 Correlations between activities of daily living assessed from disease-specific Health-related Quality of Life instruments and exercise tolerance

Activities of Daily Living	Exercise Tolerance	Correlation
CRQ Dyspnea ([16])	6 MW distance	0.46
CRQ Dyspnea ([61])	6 MW distance	0.52
CRQ Dyspnea ([52])	6 MW distance	0.26
CRQ Dyspnea ([62])	Bike VO2 peak	0.48
CRQ Dyspnea ([68])	TM VO2 peak	0.14
SGRQ Activities ([49])	6 MW distance	−0.59
SGRQ Activities ([63])	6 MW distance	−0.45
SGRQ Activities ([50])	6 MW distance	−0.58
SGRQ Activities ([62])	Bike VO2 peak	−0.56
SOLDQ Physical Function ([51])	6 MW distance	0.38
SOLDQ Physical Function ([57])	6 MW distance	0.48

6 MW = 6-minute walk, CRQ = Chronic Respiratory Disease

Questionnaire, SGRQ = St. George's Respiratory Disease

Questionnaire, SOLDQ = Seattle Obstructive Lung Disease

Questionnaire, TM = treadmill, VO_{2 peak} = peak oxygen consumption.

Table 3 Correlations between activities of daily living assessed from activity specific instruments and exercise tolerance

Activities of Daily Living	Exercise Tolerance	Correlation
Additive Activities Profile ([38])	VO2 peak	0.83
Additive Activities Profile ([64])	6 MW distance	0.45–0.61
Pulmonary Functional Status Scale ([65])	12 MW distance	0.67
Pulmonary Functional Status Scale ([39])	12 MW distance	0.62
Pulmonary Functional Status Scale ([66])	6 MW distance	0.73
Pulmonary Functional Status Scale and Dyspnea Questionnaire—Function Scale ([40])	VO2 peak	−0.41
Pulmonary Functional Status Scale and Dyspnea Questionnaire—Function Scale ([45])	6 MW distance	0.34
Shortness of Breath Questionnaire ([32])	6 MW distance	−0.68
Shortness of Breath Questionnaire ([56])	6 MW distance	−0.37
	Wmax	−0.34
London Chest Activity of Daily Living ([80])	Shuttle Walk	−0.58
Activities of Daily Living Questionnaire ([69])	6 MW distance	0.64
Physical Function Questionnaire ([68])	VO2 peak	−0.38

6 MW = 6-minute walk, 12 MW = 12-minute walk, VO_{2 peak} = peak oxygen consumption, Wmax = maximal work rate performed on a cycle ergometer.

Table 4 Correlation between generic Health-related Quality of life and exercise tolerance

HRQoL Generic Instruments	Exercise Tolerance	Correlation
Quality of Well-Being ([56])	6 MW distance	0.24
	Wmax	0.19
Quality of Well-Being ([81])	TM time	0.41–0.54
Quality of Well-Being ([52])	6 MW distance	0.12
Sickness Impact Profile ([52])	6 MW distance	0.16
Sickness Impact Profile ([60])	Wmax	−0.30
Sickness Impact Profile ([59])	6 MW distance	−0.65

6 MW = 6-minute walk, HRQoL = Health-related Quality of Life, TM = treadmill, Wmax = maximal work rate performed on a cycle ergometer.

Table 5 Correlations between disease specific Health-related Quality of Life and exercise tolerance

HRQoL Disease Specific Instruments	Exercise Tolerance	Correlation
SGRQ ([49])	6 MW distance	−0.61
SGRQ ([63])	6 MW distance	−0.40
SGRQ ([71])	Cycle VO2 peak	−0.54
SGRQ ([62])	Cycle VO2 peak	−0.51
SGRQ ([50])	6 MW distance	−0.42
SGRQ ([56])	6 MW distance	−0.26
	Wmax	−0.23
CRQ ([61])	6 MW distance	0.52
CRQ ([45])	6 MW distance	0.28
CRQ ([69])	6 MW distance	0.18
CRQ ([71])	Cycle VO2 peak	0.42
CRQ ([62])	Cycle VO2 peak	0.40

6 MW = 6-minute walk, HRQoL = Health-related Quality of Life, CRQ = Chronic Respiratory Disease Questionnaire, SGRQ = St. George's Respiratory Disease Questionnaire, VO_{2 peak} = peak oxygen consumption. Wmax = maximal work rate performed on a cycle ergometer.

Table 6 Correlations between changes in activities of daily living and changes in exercise tolerance measures following exercise training

Activities of Daily Living	Exercise Tolerance	Correlation
SF-36 Physical ([57])	6 MW Distance	0.06
SF-36 Physical ([56])	6 MW Distance	0.10
CRQ Dyspnea ([52])	6 MW Distance	0.26
CRQ Dyspnea ([75])	6 MW Distance	0.21
Shortness of Breath Questionnaire ([56])	6 MW Distance	−0.13
London Chest Activity of Daily Living ([76])	Shuttle Walk	−0.28

6 MW = 6-minute walk, CRQ = Chronic Respiratory Disease Questionnaire.

Table 7 Correlations between changes in health-related quality of life and changes in exercise tolerance measures following exercise training

Health-related Quality of Life	Exercise tolerance	Correlation
SF-36 ([77])	Cycle VO2 peak	NS
SF-36 ([78])	6 MW Distance	0.16
SF-36 ([56])	6 MW Distance	0.10
Quality of Well-Being Scale ([48])	TM Time	0.40
Quality of Well-Being Scale ([56])	6 MW Distance	0.11
Quality of Well-Being Scale ([61])	6 MW Distance	0.12
Sickness Impact Profile ([61])	6 MW Distance	0.16
CRQ ([61])	6 MW Distance	0.07–0.28
SGRQ ([50])	6 MW Distance	0.28
SGRQ ([56])	6 MW Distance	−0.15
Visual Analogue Scale 8 ([50])	6 MW Distance	0.21

6 MW = 6-minute walk, CRQ = Chronic Respiratory Disease

Questionnaire, SGRQ = St. George's Respiratory Disease

Questionnaire, VO_{2 peak} = peak oxygen consumption.

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