Reproducibility of Ventilatory Parameters, Dynamic Hyperinflation, and Performance in the Glittre-ADL Test in COPD Patients

Figures & data

Table 1. Characteristics of the subjects.

	Mean ± SD n = 23
Age, years	65 ± 6
Weight, kg	70.0 ± 13.1
Height, m	1.64 ± 0.06
BMI, kg/m^2	25.7 ± 4.5
Smoking history, pack-years	61.1 ± 31.4
GOLD 2, n	7
GOLD 3, n	7
GOLD 4, n	9
FEV1/FVC, L	0.47 ± 0.10
FEV1, L	1.08 ± 0.45
FEV1, %pred.	37.2 ± 15.4
FVC, L	2.23 ± 0.64
FVC, %pred.	60.5 ± 16.6
MVVpred. L/min	40.6 ± 17.1

kg: kilogram; m: meters; BMI: body mass index; GOLD: Global Initiative for Chronic Obstructive Lung Disease; FEV₁: forced expiratory volume in first second; FVC: forced vital capacity; L: liters; %pred.: %predicted; MVVpred: maximal voluntary ventilation predicted.

Figure 1. Bland–Altman plot of the difference between two TGlittre plotted against the mean value of the first (1) and second (2) TGlittre for the entire group of patients. The central dotted line corresponds to the average difference between two TGlittre (−0.34 minute), whereas the lower and upper dotted lines correspond to lower (−1.58 minute) and upper (0.90 min) limits of agreement, respectively.

Table 2. Reproducibility of final ventilatory parameters and performance in the TGlittre.

	TGlittre1 Mean ± SD	TGlittre2 Mean ± SD	p	ICC (95% CI)
Tinsp, ms	775 ± 180	815 ± 197	0.09	0.83 (0.63–0.92)^*
Texp, ms	1235 ± 214	1246 ± 253	0.37	0.69 (0.39–0.86)^*
Tinsp/Ttot rate	0.38 ± 0.06	0.40 ± 0.07	0.09	0.87 (0.71–0.94)^*
Vinsp, mL	1151 ± 352	1190 ± 315	0.09	0.95 (0.89–0.98)^*
VE, L/min	31.0 ± 8.5	30.4 ± 8.9	0.48	0.88 (0.73–0.95)^*
RR, bpm	30.6 ± 5.20	29.3 ± 4.76	0.03	0.45 (0.07–0.72)^*
VE/MVV	0.83 ± 0.23	0.82 ± 0.26	0.76	0.89 (0.76–0.95)^*
IC, L	1.96 ± 0.54	1.95 ± 0.46	0.96	0.90 (0.78–0.96)^*
BORG	3 [0 – 9]^#	3 [0 – 7]^#	<0.01	0,92 (0,84–0,96)^*
Time, min	5.36 ± 2.65	5.01 ± 2.79	0.01	0.97 (0.90–0.99)^*

TGlittre: Glittre ADL-test; ICC: intraclass correlation coefficient; CI: confidence interval; T_insp: inspiratory time; ms: milliseconds; T_exp: expiratory time; T_insp: inspiratory volume; mL: milliliters; V_inspmax: maximal inspiratory volume; V_exp: expiratory volume; VE: minute ventilation; L/min: liters per minute; RR: respiratory rate; bpm: breaths per minute; VE/MVV: ventilatory demand; IC: inspiratory capacity; L: liters; min: minutes.

^* p < 0.05 for ICC;, ^#: median [minimum–maximum]

Table 3. Reproducibility of changes in ventilatory parameters and DH for the TGlittre.

	TGlittre1 Mean ± SD	TGlittre2 Mean ± SD	P	ICC (95% CI)
ΔTinsp, ms	−96.6 ± 210	−164 ± 310	0.57	0.57 (0.23–0.79)^*
ΔTexp, ms	−409 ± 437	−521 ± 464	0.31	0.38 (−0.04–0.67)^*
ΔVinsp, mL	424 ± 301	418 ± 265	0.89	0.66 (0.35–0.84)^*
ΔVE, L/min	15.9 ± 6.70	16.3 ± 6.69	0.64	0.84 (0.65–0.93)^*
ΔRR, bpm	5.71 ± 6.67	6.07 ± 4.92	0.81	0.28 (−0.15–0.62)
ΔVE/MVV	0.41 ± 0.14	0.42 ± 0.15	0.75	0.64 (0.31–0.83)^*
DH, L	−0.20 ± 0.22	−0.22 ± 0.16	0.59	0.31 (−0.13–0.64)
DH, %	−9.35 ± 10.4	−10.5 ± 8.4	0.66	0.37 (−0.06–0.68)^*

TGlittre: Glittre ADL-test; Δ: change (final – rest values); ICC: intraclass correlation coefficient; CI: confidence interval; T_insp: inspiratory time; ms: milliseconds; T_exp: expiratory time; T_insp: inspiratory volume; mL: milliliters; V_inspmax: maximal inspiratory volume; V_exp: expiratory volume; VE: minute ventilation; L/min: liters per minute; RR: respiratory rate; bpm: breaths per minute; MVV: maximal voluntary ventilation; DH: dynamic hyperinflation; L: liters.

^* p < 0.05 for ICC.

Figure 2. Bland–Altman plot of the difference between the DH of the two TGlittre plotted against the mean value of the first (1) and second (2) TGlittre for the entire group of patients. The central dotted line corresponds to the average difference between two DH (−0.18 L), whereas the lower and upper dotted lines correspond to lower (−1.26 L) and upper (0.90 L) limits of agreement, respectively.

O'Donnell DE, Webb KA. The major limitation to exercise performance in COPD is dynamic hyperinflation. J Appl Physiol 2008; 105(2):753–755.

 PubMed Web of Science ®Google Scholar

Marin JM, Carrizo SJ, Gascon M, Sanchez A, Gallego B, Celli BR. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163(6):1395–1399.

 PubMed Web of Science ®Google Scholar