COPD Assessment Test (CAT) is a Valid and Simple Tool to Measure the Impact of Bronchiectasis on Affected Patients

Figures & data

Table 1. Patients characteristics.

Variables	N = 100
Age, years old	48 ± 14
Height, cm	157.6 ± 17.9
Weight, kg	61.3 ± 14.8
BMI, kg/m^2	24.1 ± 5.4
FVC, L (% pred)	2.2 ± 0.9 (67.0 ± 21.9)
FEV1, L (% pred)	1.4 ± 0.6 (51.9 ± 24.7)
FEV1/FVC	62.2 ± 15.7
mMRC (a)	2 (1–3)
E-FACED^a	3 (2–4)
E-FACED mild/moderate/severe, %	56/39/5
Bronchiectasis severity index (a)	6.5 (5–9.7)
Bronchiectasis severity index low/intermediate/high risk, %	18/52/30
Chronic infection by Pseudomonas aeruginosa (%)	58
Number of steps (a)	8,754 (5,534–11,157)
DW, m (% pred)	441.9 ± 158.0 (53.9 ± 18.2)
VO2 peak, ml/kg/minute (% pred)	17.4 ± 6.3 (60.2 ± 18.0)
Workload, watts	73.3 ± 38.1 (62.4 ± 24.1)

BMI = body mass index; DW = distance walked; E-FACED = score of bronchiectasis severity; FVC = forced vital capacity; FEV₁ = forced expiratory volume at the 1st second of FVC; mMRC = modified medical research council; VO₂ = oxygen uptake at cardiopulmonary exercise test. (a): data described as median (interquartile range IQR)

Figure 1. Cumulative frequency distribution of CAT score.

Table 2. Impact of CAT between the variables of different tests.

	Variables
CAT	mMRC	E-FACED	SGRQ (% prev)	Walk distance (m)	VO2 (ml/kg/minute)	Workload (watts)	Number of steps	BSI
0–10 Low impact (n = 14)	1 (0–2)^a	2 (1.7–3.2)	25.0 ± 12.4^a	581 ± 122	22 ± 9^a	97 ± 44	10.372 (8.697–140.849)^a	6 (5–7.2)
11–20 Medium impact (n = 40)	2 (2–3)	3 (2–4)	46.4 ± 15.0^b	468 ± 158	17 ± 5^d	80 ± 39	10.370 (7.167–12.464)^b	6 (5–8)
21–30 High impact (n = 32)	2 (1–3)	4 (2.2–5)^d	61.9 ± 12.5^c	392 ± 119^d	14 ± 3	60 ± 25^d	6.965 (3.854–9.209)	8 (5–10)
31–40 Very high impact (n = 14)	2 (1–4)	4 (2–4.5)	74.8 ± 15.4	339 ± 158^d,^e	14 ± 4	57 ± 38^d	5.642 (4.754–8.011)	9.5 (4.5–11.2)

^a p<.05 vs. medium, high, very high impact.

^b p<.05 vs. high, very high impact.

^c p<.05 vs. high impact.

^d p<.05 vs. low impact.

^e p<.05 vs. medium impact.

BSI = bronchiectasis severity score; CAT = COPD assessment test; E-FACED = score of bronchiectasis severity; mMRC = modified medical research council scale; SGRQ: Saint George’s respiratory questionnaire (SGRQ).

Figure 2. CAT score according to bronchiectasis severity by E-FACED. *p<.05 vs. moderate and severe. Mild: E-FACED 0–3 points, moderate: E-FACED 4–6 points, and severe: E-FACED 7–9 points.

Figure 3. Bland Altman plot. The solid line indicates the reference mean bias (0.7) and the dashed lines indicate the central mean bias and the upper and lower limits of agreement between the tests (CI 95% −8.7–10.1).

Figure 4. Correlation between CAT and mMRC, E-FACED, bronchiectasis severity index (BSI), number of steps (NS), walked distance at incremental shuttle walk test, workload, and oxygen uptake (VO₂) at peak of cardiopulmonary exercise test (CPET).