PredictAAT: Accounting for Inflammation in the Diagnosis of Alpha 1 Antitrypsin Deficiency

Figures & data

Figure 1. AAT level distribution according to genotype (PI*MM, PI*MS and PI*MZ) in those with (dashed lines) and without (solid lines) the presence of inflammation, defined as CRP ≥5 mg/L and <5 mg/dL, respectively.

Reproduced from Sanders, Ponte and Kueppers. COPD 2018;15:10-16 [6]

Figure 2. Changes in AAT levels of serum following the intravenous injection of 0.2 ml typhoid-paratyphoid vaccine (arrow) in the genetically different individuals. Homozygotes for common gene: solid line, heterozygotes for AATD gene: dashed line, homozygotes for deficiency gene: dotted line. At the right: standard error of the method.

Reproduced from Kueppers, Humangenetik 1968;6:207-14 [14]

Table 1. Comparison of observed and adjusted AAT levels calculated using the algorithm in the Sanders et al. cohort [6].

	Levels of Alpha -1 Antitrypsin mg/dL
Genotype	Initial Level	Level of AAT with normal CRP	Adjusted level using the predictor algorithm
PI*MM	162	142	140
PI*MS	136	117	115
PI*MZ	104	85	89
PI*MF	161	132	141
PI*SS	115	96	91
PI*SZ	66	54	50

Adapted from Sanders, Ponte and Kueppers. COPD 2018;15:10-16.

Sanders CL, Ponte A, Kueppers F. The effects of inflammation on alpha 1 antitrypsin levels in a national screening cohort. COPD. 2018;15(1):10–16. DOI:10.1080/15412555.2017.1401600

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Kueppers F. Genetically determined differences in the response of alpha-antitrypsin levels in human serum to typhoid vaccine. Humangenetik. 1968;6(3):207–214. DOI:10.1007/BF00291864

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