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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 19, 2022 - Issue 1
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Research Articles

Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China

Dingyi Wanga China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Guohui Fana China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Sinan Wub Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Ting Yangc Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
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Jianying Xud Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, ChinaView further author information
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Lan Yange Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaView further author information
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Jianping Zhaof Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaView further author information
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Xiangyan Zhangg Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s Hospital, Guiyang, ChinaView further author information
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Chunxue Baih Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaView further author information
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Jian Kangi Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, ChinaView further author information
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Pixin Ranj State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
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Huahao Shenk Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, ChinaView further author information
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Fuqiang Wenl State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaView further author information
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Kewu Huangm Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Yahong Chenn Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, ChinaView further author information
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Tieying Suno Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China; National Center of Gerontology, Beijing Hospital, Beijing, ChinaView further author information
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Guangliang Shanp Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Beijing, ChinaView further author information
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Yingxiang Linm Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Guodong Xua China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Ruiying Wangd Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, ChinaView further author information
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Zhihong Shie Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaView further author information
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Yongjian Xuf Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaView further author information
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Xianwei Yeg Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s Hospital, Guiyang, ChinaView further author information
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Yuanlin Songh Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaView further author information
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Qiuyue Wangi Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, ChinaView further author information
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Yumin Zhouj State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
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Wen Lik Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, ChinaView further author information
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Liren Dingk Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, ChinaView further author information
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Chun Wanl State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaView further author information
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Wanzhen Yaon Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, ChinaView further author information
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Yanfei Guoo Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China; National Center of Gerontology, Beijing Hospital, Beijing, ChinaView further author information
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Fei Xiaoq National Center of Gerontology, Beijing Hospital, Beijing, ChinaView further author information
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Yong Lum Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Xiaoxia Pengr Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaView further author information
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Biao Zhangp Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Beijing, ChinaView further author information
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Dan Xiaos Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, ChinaView further author information
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Zuomin Wangt Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaView further author information
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Xiaoning Bum Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Hong Zhangm Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Xiaolei Zhangc Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
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Li Anm Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Shu Zhangm Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Jianguo Zhuq National Center of Gerontology, Beijing Hospital, Beijing, ChinaView further author information
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Zhixin Caom Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Qingyuan Zhanc Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
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Yuanhua Yangm Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaView further author information
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Lirong Liangu Department of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-9944-3025View further author information
ORCID Icon,
Huaping Daic Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
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Bin Caoc Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0001-6991-0350View further author information
ORCID Icon,
Jiang Hev Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USAView further author information
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Chen Wangw Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. ChinaCorrespondence[email protected]
View further author information
& for the China Pulmonary Health (CPH) Study Group show all
Pages 118-124 | Received 29 Nov 2021, Accepted 10 Feb 2022, Published online: 06 Apr 2022

Figures & data

Figure 1. Flowchart of involving subjects. Abbreciation: COPD, chronic obstructive pulmonary disease.

Figure 1. Flowchart of involving subjects. Abbreciation: COPD, chronic obstructive pulmonary disease.

Table 1. Comparison of characteristics between development and validation dataset.

Table 2. Results of logistic regression and scores in development set.

Figure 2. Distribution of clusters of questions in the screening questionnair among different range of score in development dataset. BMI, body-mass index.

Figure 2. Distribution of clusters of questions in the screening questionnair among different range of score in development dataset. BMI, body-mass index.

Figure 3. ROC for screening questionnaire in development set (A. AUC = 0.7737) and validation set (B. AUC = 0.7711). Abbreviation: AUC, area under curve.

Figure 3. ROC for screening questionnaire in development set (A. AUC = 0.7737) and validation set (B. AUC = 0.7711). Abbreviation: AUC, area under curve.

Table 3. Accuracy, Positive and negative predictive values for COPD across different score thresholds.

Figure 4. Individual COPD probability regarding the screening questionnaire score within 95% confidence intervals. Curved blue area representitive the 95% confidence intervals for predicted COPD probability at each score level. Abbreciation: COPD, chronic obstructive pulmonary disease.

Figure 4. Individual COPD probability regarding the screening questionnaire score within 95% confidence intervals. Curved blue area representitive the 95% confidence intervals for predicted COPD probability at each score level. Abbreciation: COPD, chronic obstructive pulmonary disease.

Data availability statement

Enquiries for data generated or analyzed during this study can be directed to the corresponding author.

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