Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD

Figures & data

Figure 1. Small airway wall thickness (A) and volume fraction (Vv) of CD8 and granzyme B-positive cells (B) in small airway walls of nonsmoking control, panlobular emphysema (PLE) and centrilobular emphysema (CLE) lungs [63].

Figure 2. CD8 (brown; A) and GzmB (red; B) staining in serially sectioned slides of the small airway wall of a subject with centrilobular emphysema (X 200). Double staining for CD8 (brown) and granzyme B (red) in the small airway wall of the same subject (C and D respectively; X 400) [63].

Figure 3. The relationship between the number of alveolar granzyme B+ cells and FEV₁% predicted (A) and that between CD8+ cells and FEV₁% predicted (B) in subjects with centrilobular emphysema [69].

Figure 4. Number of GzmB+ cells (A) and CD8+ cells (B) in the alveolar walls of subjects with centrilobular emphysema with FEV₁ below 80% predicted and those with FEV₁ 80% predicted or more [69].

Figure 5. The relationship between the volume fraction (Vv) of granzyme B+ cells in small airways and FEV₁% predicted in subjects with centrilobular emphysema (CLE). P value for spearman’s rank correlation coefficient is applied to CLE subjects (A) and that between lung tissue expression of granzyme B, measured by enzyme-linked immunosorbent assay and FEV₁% predicted in smokers with FEV₁ less than 80% predicted (B) [63].

Kim WD, Chi HS, Choe KH, et al. A possible role for CD8+ and non-CD8+ cell granzyme B in early small airway wall remodelling in centrilobular emphysema. Respirology. 2013;18(4):688–696. doi: 10.1111/resp.12069.

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