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Molecular Crystals and Liquid Crystals Volume 500, 2009 - Issue 1: Proceedings of the 8th National Meeting of the Italian Liquid Crystal Society (SICL)
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Original Articles

Interaction of Human Amylin with Phosphatidylcholine and Phosphatidylserine Membranes

Michele Francesco Maria Sciacca Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, Italy
,
Vincenzo Carbone Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, Italy
,
Matteo Pappalardo Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, Italy
,
Danilo Milardi Istituto CNR di Biostrutture e Bioimmagini – Sezione di Catania, Catania, Italy
,
Carmelo La Rosa Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, Italy
&
Domenico Maria Grasso Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, ItalyCorrespondence[email protected]
Pages 73-81 | Published online: 18 Mar 2009
 
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Abstract

We studied the interaction of human amylin with dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylserine vesicles using differential scanning calorimetry, circular dichroism and molecular modelling. The results suggest that inappropriate insertion of amylin into the hydrophobic core of a lipid bilayer could hinder the secretion of amylin from pancreatic β-cells.

Acknowledgments

This research was financially supported by MIUR (FIRB [Ncirc] RBNE03PX83, PRIN 2005035119002) and University of Catania.

Notes

aInitially hIAPP adopts an α-helix conformation, but rapidly converts into β-sheet structure [Citation13].

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