Ricinoleic Acid Encapsulation into Ethyl Cellulose Electrospun Fibers

ABSTRACT

Ricinoleic acid (RA), non-irritant, shows a pro- or anti-inflammatory action following its topical application. However, RA goes rancid when it is exposed to oxygen. Encapsulation of RA into ethyl cellulose (EC) electrospun fibers is the approach. RA was extracted from castor oil and characterized. Electrospinning parameters of EC, dissolved in 2:3 dimethylformamide:acetone, were optimized to obtain bead-free fibers. A 1–8 µm EC fibers were obtained at 20 kV, 0.5 mL/h feeding rate, and 20 cm air gap. RA at different concentrations was encapsulated into EC fibers. Release profile was reported and encapsulation was demonstrated via morphological analysis.

摘要

蓖麻油酸(RA)无刺激性，局​​部应用后还具有促炎或抗炎作用。然而，RA在暴露于氧气时容易变质发臭。一种解决办法是将RA封装为乙基纤维素(EC)电纺纤维。RA从蓖麻油中提取并特征化。EC溶解在二甲基甲酰胺和丙酮2:3溶液中以优化其静电参数，从而获得无珠纤维。在20 kV、0.5 mL/h进料速度和20cm空隙条件下获得1-8μm的EC纤维。不同浓度的RA被封装为EC纤维。本文报告了释放曲线，并通过形态分析展示了封装效果。

KEYWORDS:

• Electrospinning
• encapsulation
• ethyl cellulose
• ricinoleic acid

关键词:

• 静电纺丝
• 封装
• 乙基纤维素
• 蓖麻油酸

Acknowledgments

Authors are grateful to National Research Centre (Scopus affiliation ID: 60014618) for facilities provided. The authors have declared no conflicts of interest.