Fabrication and characterization of novel antibacterial silk sutures with different braiding parameters

ABSTRACT

We explored novel antibacterial braided silk sutures based on levofloxacin hydrochloride and polycaprolactone to obtain sustained-release antibacterial efficacy. This study focused on the effect of braiding parameters on the antibacterial efficacy of braided silk sutures. A series of braids was fabricated with different take-up speeds obtained by changing cogwheel ratios on a circular braiding machine. Antibacterial efficacy, drug release characteristics, and mechanical property were analyzed. Antibacterial specimens showed ideal bacterial reduction. In the drug release profiles, braided silk sutures manufactured at higher cogwheel ratios showed a less significant initial drug burst. In addition, the total drug release amount after 5 days was similar for all samples. Hence, the result of drug release profiles may give some inspiration for the control of drug release in the manufacture of antibacterial braided silk sutures. Moreover, all the samples fulfilled the knot-pull tensile strength requirement of the U.S. Pharmacopeia.

摘要

探索了以盐酸左氧氟沙星为载体的新型抗菌编织丝线，获得了缓释抗菌效果。研究编织参数对编织丝线抗菌效果的影响。一系列的抗菌编织丝线是通过改变圆形编织机的齿轮比以改变卷曲速度而制作的。对抗菌效果、释药特性和力学性能进行了分析。抗菌标本显示理想的细菌减少。在药物释放曲线中，较高齿轮比制造的编织丝线突释现象不明显。此外，所有样品5天后的总药物释放量是相似的。因此，药物释放曲线的结果对抗菌编织丝线的药物释放控制有一定的启发。此外，所有样品打结抗张强度满足美国药典要求

KEYWORDS:

• Surgical silk sutures
• braiding parameters
• antibacterial properties
• levofloxacin hydrochloride
• sustained release
• knot-pull tensile strength

关键词:

• 外科丝线
• 编织工艺参数
• 抗菌性能
• 盐酸左氧氟沙星
• 持续释放
• 拉结抗拉强度

Additional information

Funding

This work was supported by the 111 project “Biomedical Textile Materials Science and Technology” (grant number B07024), Fundamental Research Funds for the Central Universities (grant number 16D110119) of Ministry of Education of China, and Ningbo Science and Technology Key Project (grant number 2017C110037).