Assessment of occupational exposure to nebulized isopropyl alcohol as disinfectant during aseptic compounding of parenteral cytotoxic drugs in cleanrooms

Figures & data

Figure 1. Transferring the vials with cytotoxic drugs into the plastic bag.

Figure 2. Disinfecting the vials by spraying IPA into the plastic bag.

Table 1. Average exposure to IPA and peak concentration IPA.

Measurement day	Measurement duration (min)	Cumulative exposure (mg/m^3)	8-hr TWA exposure to IPA (mg/m^3)	Highest peak concentration measured as the 1-min TWA (mg/m^3)
#1	425	1102	2.6	155.1
#2	423	7330	17.3	860.2
#3	449	1582	3.5	172.7
#4	495	12935	26.1	342.3
#5	438	4898	11.2	167.1
#6	132	5799	43.9	199.2

Table 2. Average exposure to IPA of two disinfection methods.

Measurement day	Measurement duration (min)	Cumulative exposure (mg/m^3)	8-hr TWA exposure to IPA of method 1 (mg/m^3)	Measurement duration (min)	Cumulative exposure (mg/m^3)	8-hr TWA exposure to IPA of method 2 (mg/m^3)
#1	245	666	2.7	179	435	2.4
#2	199	868	4.4	219	6,462	29.5
#3	250	1,351	5.4	199	231	1.2
#4	272	4,567	16.8	223	8,367	37.5
#5	254	4,259	16.8	184	638	3.5
#6	177	5,799	32.8	N/A	N/A	N/A