Comparison of early vascular morphological changes between bioresorbable poly-L-lactic acid scaffolds and metallic stents in porcine iliac arteries

Figures & data

FIGURE 1. Digital subtraction angiography images of the porcine iliac arteries before stent implantation (A), immediately after stent implantation (B) and 6 weeks after stent implantation (C). The Igaki-Tamai stent was placed in the right iliac artery, and a bare metal stent was placed in the left iliac artery. Each arrow shows an edge of the implanted stents.

TABLE 1. Comparison of the results of intravascular ultrasound analysis between Igaki-Tamai stents (ITSs) and bare metal stents (BMSs).

	ITSs	BMSs	P-value
Pre-implantation
Vessel lumen area (mm^2)	22.55 ± 2.23	24.36 ± 1.53	.508
Immediately after implantation
Vessel lumen area (mm^2)	29.62 ± 1.71	36.60 ± 0.68	.001
6-week follow-up
Vessel lumen area (mm^2)	8.34 ± 0.95	12.42 ± 1.63	.041
Vessel lumen diameter (mm)	3.25 ± 0.13	3.87 ± 0.21	.018
EEL area (mm^2)	24.00 ± 1.53	38.11 ± 1.07	<.001
EEL diameter (mm)	5.51 ± 0.13	6.92 ± 0.17	<.001
Neointimal area plus media area (mm^2)^a	15.65 ± 1.15	25.69 ± 1.80	<.001

EEL: external elastic lamina

Data are presented as mean ± standard error of the mean.

^a The neointimal area plus media area was calculated as the EEL area minus the vessel lumen area measured at 6-week follow-up.

FIGURE 2. Intravascular images of the vessels before stent implantation (A), implanted with Igaki-Tamai stents (B, C) and bare metal stents (D, E) immediately after stent implantation (B, D) and 6 weeks after stent implantation (C, E).

FIGURE 3. Graph A shows percent vessel lumen change with Igaki-Tamai stents (ITSs) and bare metal stents (BMSs). Graph B shows percent area stenosis with ITSs and BMSs at 6-week follow-up. Graph C shows vascular remodeling with ITSs and BMSs at 6-week follow-up.

TABLE 2. Comparison of the results of histomorphometric analysis between Igaki-Tamai stents (ITSs) and bare metal stents (BMSs) at 6 weeks after stent implantation.

	ITSs	BMSs	P-value
Neointimal area (mm^2)	5.8 ± 0.54	16.8 ± 1.61	<.001
Media area (mm^2)	5.1 ± 0.57	3.1 ± 0.13	.002

Data are presented as mean ± standard error of the mean.

FIGURE 4. Representative photomicrographs of hematoxylin-eosin-stained sections of the porcine iliac arteries 6 weeks after stent implantation. (A) Igaki-Tamai stent. (B) Bare metal stent. (C) Non-stented segment.

TABLE 3. Comparison of the results of histopathological analysis between Igaki-Tamai stents (ITSs) and bare metal stents (BMSs).

	ITSs	BMSs	P-value
Inflammation score	0.073 ± 0.021	0.027 ± 0.010	.062
Injury score	0.053 ± 0.014	0.023 ± 0.009	.085

Data are presented as mean ± standard error of the mean.