Figures & data
Figure 1. Examples of methylated and oxidized bases found in RNA and DNA.
Figure 2. Mechanism of methylation leading to the formation of het-CH3 and C-CH3 connectivities in RNA and DNA.
Figure 3. Oxidation of m6A followed by decomposition of the hemiaminal to A and oxidation if 5mdC to stable 5hmdC.
Figure 4. Potential mechanism of chemically induced active demethylation with a potential immediate re-methylation.
Figure 5. Active demethylation via base excision repair. Two possibilities are discussed: A direct removal of 5fdC and 5cadC in xdC:dG base pairs or removal of a deaminated 5hmdU in a 5hmdU:dG mismatch by BER glycosylase.
