https://orcid.org/0000-0003-1873-0557
Figures & data
Figure 1. Timeline overview of SNORD118/U8 snoRNA discovery, annotation, and implication in LCC.
Figure 2. Pathologies of LCC (purple) are mapped alongside genetic information (yellow) and cartoon of brain disease (green).
Figure 3. Structure of U8 snoRNA. A) Secondary structure of mature U8 snoRNA. Sequence and structure taken from [Citation21]. Orange circles refer to naturally occurring SNPs found in [Citation13]. Orange triangles refer to nucleobase insertions. Yellow circle is trimethylguanosine cap. Green box and black box refer to C and D box motifs, respectively. Purple hexagons are LSm motif. Boxed nucleotides refer to pre-U8 snoRNA 3′–extension from [Citation42]. Image generated using Varna [Citation44]. B) Three-dimensional computational model of U8 snoRNA. Sequence and secondary structure from [Citation21]. Model generated using RNAComposer [Citation45,Citation46]. Colour scheme corresponds to those mapped onto A.
![Figure 3. Structure of U8 snoRNA. A) Secondary structure of mature U8 snoRNA. Sequence and structure taken from [Citation21]. Orange circles refer to naturally occurring SNPs found in [Citation13]. Orange triangles refer to nucleobase insertions. Yellow circle is trimethylguanosine cap. Green box and black box refer to C and D box motifs, respectively. Purple hexagons are LSm motif. Boxed nucleotides refer to pre-U8 snoRNA 3′–extension from [Citation42]. Image generated using Varna [Citation44]. B) Three-dimensional computational model of U8 snoRNA. Sequence and secondary structure from [Citation21]. Model generated using RNAComposer [Citation45,Citation46]. Colour scheme corresponds to those mapped onto A.](/cms/asset/2a6609ee-adfc-4d8d-9eb9-c1ba18ac70ef/krnb_a_2048563_f0003_oc.jpg)