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Review

Small molecule inhibition of RNA binding proteins in haematologic cancer

, , , , &
Pages 1-14 | Accepted 05 Jan 2024, Published online: 08 Feb 2024

Figures & data

Figure 1. Schematic of RNA homoeostasis. Gene expression initates with transcription of DNA into a pre-mRNA. Numerous steps of RNA processing occur, many in parallel with transcription. A separate pathway of microRNA (miRNA) processing occurs for primary transcripts that encode miRNAs. Please see text for further details. Schematic created at Biorender.com.

Figure 1. Schematic of RNA homoeostasis. Gene expression initates with transcription of DNA into a pre-mRNA. Numerous steps of RNA processing occur, many in parallel with transcription. A separate pathway of microRNA (miRNA) processing occurs for primary transcripts that encode miRNAs. Please see text for further details. Schematic created at Biorender.com.

Figure 2. Small molecule inhibitors of pre-mRNA splicing. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 2. Small molecule inhibitors of pre-mRNA splicing. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 3. Inhibitors of RNA modification and nuclear export. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 3. Inhibitors of RNA modification and nuclear export. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 4. Inhibitors of microRNA processing. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 4. Inhibitors of microRNA processing. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 5. Small molecules targeting regulators of mRNA stability. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 5. Small molecules targeting regulators of mRNA stability. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 6. Inhibitors of protein translation and sequestration. *Mechanism of action for inhibition not reported. Please see text for further details.

Figure 6. Inhibitors of protein translation and sequestration. *Mechanism of action for inhibition not reported. Please see text for further details.
Supplemental material

Supplementary_Table_Structures.pdf

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