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Research Article

Interlaboratory Study of the Primary Antibody Response to Sheep Red Blood Cells in Outbred Rodents Following Exposure to Cyclophosphamide or Dexamethasone

Scott E. Loveless DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware

Gregory S. Ladics DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware

Charlene Smith DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware

Michael P. Holsapple Dow Chemical Company, Midland, Michigan

Michael R. Woolhiser Dow Chemical Company, Midland, Michigan

Kimber L. White Jr. Virginia Commonwealth University, Richmond, Virginia

D. L. Musgrove Virginia Commonwealth University, Richmond, Virginia

Ralph J. Smialowicz Office of Research and Development, Experimental Toxicology Division, U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle ParkNorth Carolina

W. Williams Office of Research and Development, Experimental Toxicology Division, U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle ParkNorth Carolina

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Figures & data

FIG. 1 Cyclophosphamide Inhibition of the Antibody Response to sRBC from a Representative Laboratory. Dose response curves for percent inhibition were plotted in Microsoft Excel, a best-fitting trendline drawn, and the dose of each compound to inhibit the response (AFC: Antibody Forming Cell/10⁶ splenocytes; AFC spleen: AFC/spleen; ELISA) by 50% (ID₅₀) in rats (R) or mice (M) was visually determined.

TABLE 1 Lowest dose of cyclophosphamide at which statistical significance was observed and percent inhibition

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TABLE 2 Cyclophosphamide ID₅₀ values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

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TABLE 3 Lowest dose of dexamethasone at which statistical significance was observed and percent inhibition

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TABLE 4 Dexamethasone ID₅₀ values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

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Interlaboratory Study of the Primary Antibody Response to Sheep Red Blood Cells in Outbred Rodents Following Exposure to Cyclophosphamide or Dexamethasone

TABLE 1 Lowest dose of cyclophosphamide at which statistical significance was observed and percent inhibition

TABLE 2 Cyclophosphamide ID₅₀ values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

TABLE 3 Lowest dose of dexamethasone at which statistical significance was observed and percent inhibition

TABLE 4 Dexamethasone ID₅₀ values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

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Interlaboratory Study of the Primary Antibody Response to Sheep Red Blood Cells in Outbred Rodents Following Exposure to Cyclophosphamide or Dexamethasone

Figures & data

TABLE 1 Lowest dose of cyclophosphamide at which statistical significance was observed and percent inhibition

TABLE 2 Cyclophosphamide ID50 values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

TABLE 3 Lowest dose of dexamethasone at which statistical significance was observed and percent inhibition

TABLE 4 Dexamethasone ID50 values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

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TABLE 2 Cyclophosphamide ID₅₀ values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression

TABLE 4 Dexamethasone ID₅₀ values from all four laboratories using the AFC and ELISA assays to evaluate immunosuppression